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This hypothesis must be corroborated by further in vitro and in vivo studies

The synbiotic intervention was found to significantly modify the gut microbiota, increase the relative abundance of Lactobacillus , Bifidobacteria , and Subdoligranulum genera, substantially lower the serum level of IS, improve eGFR, and reduce the level of high-sensitivity C-reactive protein in the treated group

Consistent with the experiments in vitro , RSL3 downregulated the elevated GPX4 in residual tumors, not FTH1 ( Figure 5I )

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