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J Cereb Blood Flow Metab 21(3):218225 Liu C, Zhang Y, Liu Q, Jiang L, Li M, Wang S, Long T, He W, Kong X, Qin G, Zhang Y, Zhou J (2018) P2 4-receptor participates in EAAT3 regulation via BDNF-TrkB signaling in a model of trigeminal allodynia

This is especially helpful when you first start taking new drugs or using a combination of treatments

I feel like, in my experience, I'll just give you a little backstory because I had Crohn's over 20 years ago, and one of the Big ahas in me completely being cured in a remission from Crohn's, like, zero symptoms