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Namely, decreased corneal sensitivity and tear formation appeared with many standard anti-glaucoma agents (i.e., latanoprost, timolol, brimonidine, and dorzolamide) [194,195,196,197]

doi: 10.1038/s41598-022-10051-z 3 Rodriguez-SanchezIRodriguez-MaasLLaosaO

Preliminary animal research suggests that DSIP levels may influence stress and withdrawal responses by interacting with opioid receptors and potentially modulating opiate receptors