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2.1 The antagonistic relationship between Th17/Treg during differentiation pathways 2.1.1 Transcription factor regulation A vital mechanism in the control of immunological homeostasis is the mutual antagonistic relationship between RORt and Foxp3 ( Figure 1 ), which is a crucial intrinsic factor affecting the differentiation pathways of Th17 and Treg cells

Additionally, iodothyronine deiodinases, which are selenium-dependent enzymes, regulate the conversion of T 4 to the biologically active T 3 (Arthur et al., 1992)

More Interestingly, trehalose which alleviated CP-induced AKI by activating autophagy (Zhu et al., 2020), recently, its pro-autophagic activity has made it also a potential treatment for CP-induced ototoxicity (Li et al., 2022b)

doi:10.1016/0014-5793(90)80922-6