vitamin b12 injections for pernicious anemia Oral Treatment BSH guidance on B12 during

Neelakantan and colleagues (Biochem Pharmacol, 2018) reported that 1-methylquinolinium and 1-methylnicotinamide showed no measurable passive diffusion in their assays, whereas 5-amino-1MQ crossed by both passive and active routes with no detectable efflux in Caco-2 cells, and lowered intracellular 1-methylnicotinamide in differentiated 3T3-L1 adipocytes with an EC near 2.3 M

Research must follow IRB or IACUC guidelines

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice. Nature Medicine, 25(11), 17611771

You don't need to kill yourself with exercise, but sitting on the couch while using AOD 9604 will produce modest results at best