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Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxia-induced mitochondrial mutagenesis in inflammatory arthritis

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Comprising the subunits solute carrier family seven member 11 (SLC7A11) and solute carrier family three member 2 (SLC3A2), System Xc is a vital antioxidant System, facilitating the 1:1 exchange of cystine and glutamate across the cell membrane (Yang and Stockwell, 2016