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Cagnacci A, Barattini DF, Casolati E, Pecoroni A, Mangrella M, Patrascu LC

"This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis," the team from China and the US writes in their published paper, "but also reveals a weight loss-independent repair mechanism." In addition to mouse experiments, the researchers also conducted a randomized human trial to assess the effects of semaglutide on pain, mobility, and tissue degradation in individuals with osteoarthritis and obesity

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This modulation impacts a range of physiological processes, including neuroprotection, mitochondrial function, and oxidative stress defense