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Foundational studies show that acetate programs T-cell responses by supplying acetyl-CoA to metabolicepigenetic nodes: during systemic stress or infection, acetate boosts memory CD8 T-cell recall via ATP-citrate-lyasedependent GAPDH acetylation, increasing glycolytic reserve and IFN- output [76]

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Individuals who were more explicitly biased against overweight individuals, individuals with a low level of empathy for overweight individuals, and who believed that people are completely responsible for their own weight showed some tendency in one study to judge GLP-1RA users more harshly, although these effects were modest and not consistently observed across both studies