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Apart from rodents of the suborder Hystricomorpha (e.g., guinea pig ( Cavia porcellus ) and degu ( Octodon degus ) with 4 differences from the human glucagon sequence), three other groups of mammals have glucagon peptide sequences that have accumulated considerable sequence difference from the human glucagon sequence: platypus ( Ornithorhynchus anatinus ) with 7 substitutions, the Malayan and Chinese pangolins ( Manis javanic a and Manis pentadactyla ) with 5 substitutions, and Brandts bat ( Myotis brandtii ) and little brown bat ( Myotis lucifugus ) with 3 substitutions ( Supplementary Table 6 )

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