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Curcumin and hydroxamate-derivative (PCI-34058) interfere with histone deacetylase I catalytic core asp-his charge relay system: atomistic simulation studies
2020 Jul 9;6(1):56
It has not been submitted for regulatory approval as a therapeutic agent
34 Fenton reaction and lipid peroxidation in hepatotoxicity According to a more recent review by Dixon and Stockwell, 35 there are three essential hallmarks that define ferroptosis: the loss of lipid peroxide repair capacity by the phospholipid hydroperoxidase GPx4, the availability of redox-active iron, and the oxidation of PUFA-containing phospholipids . Although the term ferroptosis is new, the process of iron-dependent lipid peroxidation (LPO) as a mechanism of cell death in the liver has been recognized for 60 years
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