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Also, in the context of SUDs, Bisaga warned against over-relying on a simple biological solution, which could underplay the critical role of social determinants of health and systemic inequities which greatly influence the course of SUDs and treatment response. While GLP-1 receptor agonists show promise for the treatment of SUDs, this potential must be tempered by the current lack of clinical evidence and understanding of their mechanisms, he said

Bezdek, J

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For drugs in moderately rare conditions with competitive pressure from structurally distinct molecules, the practical barrier may be weaker than the statutory term suggests