However, over time, too much sugar in our diets leads to more and more insulin being required for cellular signaling in other words, these cells have become less insulin sensitive
Another proposed mechanism involves the inhibition of the transcriptional activity of nuclear factor erythroid 2-related factor 2, a key regulator of antioxidant defense systems, by elevated levels of homocysteine
doi: 10.1016/j.ejphar.2021.174338 Summary Keywords butyrate, SCFAs, gut microbiota, obesity, metabolic disease Citation Peng K, Dong W, Luo T, Tang H, Zhu W, Huang Y and Yang X (2023) Butyrate and obesity: Current research status and future prospect
Stamler and Slivka, 1996)