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Choosing the Right Glp-1 Agonist for You Once administered, semaglutide binds to and activates the GLP-1 receptors in the pancreas, thereby stimulating insulin release and suppressing the secretion of glucagon, another hormone involved in blood sugar regulation

Type 2 diabetes mellitus (T2DM) is a complex metabolic disease in which concomitant insulin resistance and -cell impairment leads to hyperglycemia [2]

These potential pathways are summarized in Figure 5 and warrant further translational research for validation