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injections of 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice and n = 4 cages), 300 nmol kg 1 GLP-1MK-801 ( n = 8 mice and n = 4 cages) or vehicle (isotonic saline, n = 8 mice and n = 4 cages) for 14 days

improve the F/M ratio, which may contribute to weight loss, obesity-related pathologies, and gastrointestinal disorders

These findings not only validate the effectiveness of PLB in the treatment of PCOS, but also reveal its complex molecular regulatory mechanisms, especially the important role played by the YTHDF1/SLC7A5 axis

Gene expression profiling analysis shows that the expression of GPX4 and genes related to GSH synthesis in the GCB subtype is significantly lower than that in the ABC subtype, while the expression of BCL-2 in the ABC subtype is significantly higher