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The STEP 4 withdrawal trial demonstrated that discontinuation of semaglutide 2.4 mg after a 20-week run-in is followed by nearly complete weight regain within one year an outcome that is more accurately framed as disease recurrence in a chronic relapsing condition than as drug failure (Quimbayo-Cifuentes, 2026)

Obesity is a major risk factor for many chronic conditions like type 2 diabetes and cardiovascular diseases

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You can contact WRTV Investigates Kara Kenney at [email protected].