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Indeed, ROS may modulate the NF-B response leading to transcriptional activation of NF-B-target antioxidant genes (e.g., SOD , HO1 , GPX1 , TRX1 , and TRX2 ), which reduce ROS production, thereby promoting cell survival ( NOX2 , COX2 , and NOS2 ( All in all, the results of our network and enrichment analysis and Maes et al