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Environmental monitoring has also reported that fibrous MPs accumulate the most in the intestines, and exposure may exacerbate intestinal inflammation and microbial shifts [21]

This suggested that the superficial layer of the grafts had a greater viability compared to the deeper layers, consistent with Kotaros three zones theory [8]

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The cancer chemotherapy drug methotrexate is used in Crohns patients that are steroid dependent or have not responded to glucocorticoids (Preiss 2010)