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While the global burden of age-related neurodegenerative disorders is on the rise, this association is especially worrying due to the increasing global prevalence of chronic liver diseases, mainly non-alcoholic fatty liver disease (NAFLD) as well as chronic kidney disease [254,255]

Recent studies have used preclinical disease models to demonstrate the potential of pore pathway or leak pathway barrier restoration in disease

However, skin hydration, dermal thickness, transepidermal water loss (TEWL), and viscoelasticity were not significantly altered [34]

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