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Similarly, the reported onset appeared faster with the SC formulation in clinical trials of SC (510 min) relative to trials of SL (1530 min), with numerically larger reductions in UPDRS scores at early timepoints (SL: 75% administering apomorphine injections daily [31]

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Compared with 12% of PTEN loss in CM where deletions and mutations both account for the changes (79), PTEN is deeply deleted in merely 6.0% of MM cases and has hardly any mutations ( PTEN and amplified KIT that possibly implies that loss of PTEN or gain of KIT are redundant for the activation of the PI3K pathway in MM