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There may be an age-associated effect, as cultured human microglia from elderly individuals did not express Drd5 mRNA despite the presence of mRNA for the remaining dopamine receptors (Mastroeni et al., 2009)

In male patients with KRAS-mutant CRC, decreased ferritin activity has also been observed, suggesting that these tumors may depend on mitochondrial redox-buffering mechanisms to evade iron-dependent cytotoxic responses [5, 72, 73]