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Figure 29A illustrates the inhibitory response that was observed with daily intraperitoneal injections at two doses (^g/kg/day and 10(^g/kg day) of [D-Nle-Cys-ne-NH-(CH 2 )5-CONH 2 ]

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These modications extended the half-life to approximately 13 hours, allowing for once- daily subcutaneous injection