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Future studies combining -cell states defined by scRNA-seq and snATAC-seq with quantitative measures of SCFA, indole derivatives, or endotoxemia have the potential to reveal whether specific -cell subpopulations preferentially associate with distinct microbiota-derived signatures or display differential transcriptional responses to incretin- and SCFA-dependent interventions, thereby advancing a systems-level understanding of microbiota-cell interactions

[Article] [PubMed] [PMC]84

Stacking decisions are made between patient and prescribing clinician based on individual response