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KB-141 (3,5-dichloro-4-(4-hydroxy-3-isopro-pylphenoxy) phenylacetic acid) is another THR-selective agonist with clinical relevance, as it has been shown to reduce cholesterol in rats whose diet was supplemented with cholesterol and cholic acid

Studied in models involving energy expenditure, substrate utilization, hepatic signaling, and metabolic adaptation pathways

The primary outcomes were the percentage weight change and the proportion of participants losing at least 5% of their baseline weight, using treatment-policy estimand analysis (intention-to-treat principle)

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