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This triple-agonist mechanism is what makes it potentially more effective than single-agonist peptides like semaglutide , but it also means the gastrointestinal side effects can be more intense if you start too high
One study of women with polycystic ovary syndrome (PCOS) and obesity treated them with semaglutide injections for 16 weeks, in addition to the diabetes drug Metformin
After stopping the medication, participants taking semaglutide regained 11.6% of their body weight, and those taking a placebo regained 1.9%, leading to a net weight loss of 5.6% in the semaglutide group and 0.1% in the placebo group
Its pharmacological profile makes it particularly valuable for studies requiring sustained receptor activation and long-duration metabolic observations
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