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Pregnancy and breastfeeding excluded from the trial

Early first-generation senolytics, including navitoclax (ABT-263) and the dasatinibquercetin (D + Q) combination, provided proof-of-concept that selective removal of SnCs can alleviate certain fibrotic, metabolic, and cardiovascular pathologies in preclinical studies

Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults

The beneficial effects of GLP-1RAs on septic lung injury were similarly confirmed by Guo et al (60), who found that liraglutide treatment in mice with sepsis induced by bacterial pneumonia could reduce the bacterial load, improve animal survival rates, decrease lung inflammatory cells and cytokines, and enhance the production of pulmonary surfactant phospholipids and surfactant proteins A and B, thereby alleviating acute lung injury and mortality due to pneumonia-induced sepsis