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In rabbit models, intra-articular injection of scAAV2 encoding interleukin-1 receptor antagonist (IL-1Ra) yielded sustained therapeutic protein expression in both inflamed and normal joints for at least two weeks, with minimal immune activation or joint pathology (178)

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doi: 10.1016/j.neurobiolaging.2006.06.025

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15 Despite proven efficacy, there are recent safety concerns regarding sitagliptin use

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10.1002/1529-0131(199911)42:11 3.0.CO;2-Y 73 McCullochK.LitherlandG

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