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in 1988 [89, 90] and denoted as low-molecular weight proteinase inhibitors/isoinhibitors from the granular fraction of equine neutrophilic granulocytes

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Previous research suggests DSIP can influence biosynthetic processes in the brain, reduce stress protein factors, and potentially affect glutamate and GABA receptors in regions like the cortex, thalamus, and hippocampus

However, high-dose niacin (as a medication for cholesterol) is generally not recommended during breastfeeding, because significant amounts could enter milk and cause unwanted effects in the nursing infant (flushing, for example)