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In addition, when circulating L-carnitine concentration increases, as in the case of oral supplementation, renal reabsorption of L-carnitine may become saturated, resulting in increased urinary excretion of L-carnitine (5)

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These findings support PDHA1 as a promising therapeutic target to enhance Enz efficacy and overcome drug resistance in PCa

Impairments in the ability to generate ATP from canonical mitochondrial pathways, such as the TCA or electron transport chain, drive additional neurophysiological impairments even after primary injury and initial ischemia resolve