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Flushing and nausea were the top complaints, and one study noted some participants had yawning and somnolence (sleepiness), plus infrequent back pain

Y., Saito, M., Kato, H., Morikawa, K., Kikukawa, H., Nomura, H., et al

Read more this case in report by CNN

This calcium overload activates Tau kinases, such as GSK-3 and CDK5, thereby promoting Tau phosphorylation and exacerbating the pathological process of Alzheimers disease [117]