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FZEC is Eisais first ADC, developed from the companys internally developed farletuzumab, a humanized IgG1 monoclonal antibody targeting FR, and the anticancer agent eribulin, linked via an enzymatically cleavable linker

This multicenter, double-blind, placebo-controlled trial enrolled people with NAFLD with liver fat content at or above 10% by MRI-PDFF, a FibroScan liver stiffness measure below 10 kPa, alanine aminotransferase (ALT) at or below 75 IU/L, and no diabetes or non-insulin-dependent diabetes with A1C below 9.5%

However, long-term outcomes at 6 months show similar effectiveness between both delivery methods

However, the overall inhibition was limited, likely attributable to their insufficient atherosclerosis accumulation due to the absence of platelet carriers