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Research has characterised Ipamorelin-induced GH secretion kinetics in isolated somatotroph cells, anterior pituitary preparations, and in vivo rodent and primate models , examining calcium-dependent GH granule exocytosis, GH pulse amplitude and duration, somatotroph calcium dynamics following selective GHS-R1a activation, and how selective GHS-R1a signalling integrates with somatostatin inhibitory tone and GHRH stimulation to determine net somatotroph secretory output without the endocrine complexity introduced by prolactin and cortisol co-stimulation

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