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Therefore, an innovative strategy to address the multifaceted nature of AD is to identify compounds capable of modulating multiple targets [2]
Future studies should further address this possibility and, at a minimum, specify in reports the time of day at which antioxidants were administered
Ristoff E, Mayatepek E, Larsson A: Long-term clinical outcome in patients with glutathione synthetase deficiency
The absence of apoptosis in the PBMC from patients with Graves hyperthyroidism may be attributed to alterations in apoptotic signalling pathways or a lower intensity of Fas expression in these cells.25 Conversely, increased apoptosis has been found in lymphoid cell lines or in peripheral blood T lymphocytes treated in vitro with thyroid hormones for different times.26,27 Furthermore, increased apoptosis was found in PBMC from patients with untreated Graves disease after 24h of in vitro culture.27 Hara et al
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