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Some studies report noticeable effects lasting 12 hours or, in some cases, even up to 24 hours post-administration, though with diminishing intensity

doi:10.1136/bmj-2025-085304

They also tend to show up in a DEXA scan rather than a mirror, which is why most women don't connect the symptoms to the weight loss until something more dramatic - a fracture from a minor fall, for example - forces the issue

These population-based approaches contrast with traditional risk assessment methods, which often rely on animal POD data and default tenfold uncertainty factors to account for interspecies and TK/TD differences (WHO/IPCS 2010)