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13 In 1993, The Journal of Clinical Apheresis published a paper detailing the use of TPE as either a first- or second-line therapy to be used with other modalities on disorders such as Raynauds disease, systemic lupus erythematosus, coagulation factor inhibitors, familial hypercholesterolemia, acute Guillain-Barr syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, cryoglobulinemia, Goodpastures syndrome, and thrombotic thrombocytopenic purpura

The article discusses the reported rationale for the change with citation

HPLC tested for identity and purity

A vial stored in a standard home refrigerator in clear glass under interior lighting loses 1015% more potency over 28 days than an identical vial wrapped in foil or stored in amber glass