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The anticonvulsant drugs phenobarbital, phenytoin (Dilantin), and carbamazepine (Tegretol) may also lower plasma vitamin E concentrations in individuals with epilepsy (129)

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Research has shown that polymorphisms in the GLP-1 receptor gene may influence the effectiveness of treatment, affecting both appetite regulation and insulin sensitivity

Of course, it is unwise to directly compare the doses given to animals and the doses given to humans, as the bodys surface area should also be taken into account when translating doses between species