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Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

The pre-filled pen format allows researchers to streamline experiments with accurate, reproducible peptide dosing without the need for complex preparation

The Participant Center: U24 OD023176

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