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Scientists found that the venom of the Gila monster, a lizard that spends most of its time underground and only eats three to four times a year, had a hormone remarkably similar to human GLP-1 that didnt break down as quickly

A large, long-term study of semaglutide, the active ingredient in Wegovy, found that patients with obesity but without diabetes continued losing weight for 65 weeks and sustained the weight loss for up to 4 years

doi: 10.3322/CAAC.21388 146 PlichtaJKCampbellBMMittendorfEAHwangES

Clinical trials demonstrate that most participants achieve meaningful weight reduction between 1522% at the 15 mg maintenance dose, though individual results vary significantly based on metabolic and genetic factors