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The interaction very rarely results in a pernicious anemia that appears reversible with discontinuation of metformin or with Methylcobalamin, vitamin B12 supplementation

This underscores the need for thoughtful discontinuation strategies tailored to the patient, which can be challenging without clear guidelines or guidance from robust research studies

We hypothesize that mitophagy preserves mitochondrial function during hair regeneration by eliminating damaged mitochondria, thereby influencing the expression and function of Sox9, promoting the synthesis of GSH and cell proliferation within HG, and ultimately facilitating hair regeneration