The treatment of mice with daidzein and genistein (low dose 20 mg/kg or high dose 150200 mg/kg) for two weeks reversed the polyinosinic:polycytidylic acid [poly(I:C)]-induced decrease in locomotor activity and brain/skin gene expression, as well as serum levels of pro-inflammatory mediators relevant to CFS (i.e., TNF-, IL-6, keratinocytes-derived chemokine (IL-8/(CXC motif) ligand (CXC)L8 murine homolog), chemokine (CC motif) ligand-2, -4, -5 (CCL2, CCL4, CCL5) and C-X-C motif chemokine ligand 10 (CXCL10))
Nevertheless, future research should focus on examining temporal relationships between HPA axis function and immune-inflammatory or nitrosative stress pathways through biomarkers like TNF-, IL-10, TGF-, inducible NO synthase, NO production, protein nitrosylation, and bacterial translocation in ME/CFS patients to better understand their roles [79]
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