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Although eumelanin can provide some protective effects against UV-induced damage, pheomelanin may exacerbate ROS production, leading to further oxidative stress and DNA damage in melanocytes, particularly under UV exposure 118

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CuCl 2 didnt cause any change in the IL-1, IL-8 and HSPA1A protein levels at the concentration of 58 M, while the protein levels upregulated significantly with 580 M CuCl 2 treatment

Thus, we propose that SFN mediates activation of this molecular switch, and that restoration of the Nrf2/Prdx6 pathway provides a proof of concept that SFN can be considered as a therapeutic chemo-protectant to repair and reverse age-related diseases, such as cataractogenesis