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The redox-sensitive transcription factor NF-E2 related factor-2 (Nrf2) suppresses brain endothelial cell monocyte adhesion via upregulation of the redox-related mitochondrial transporter ABCB10 [24]

Such an ideal unimolecular antidiabetic agent should have complementary effects correcting multiple pathophysiological defects of T2D and be safe, durable, well-tolerated, easy to administer, and cost-effective

Most patients who stop the medication regain weight within a year

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