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In a study (New-Onset Nonarteritic Anterior Ischemic Optic Neuropathy and Initiators of Semaglutide in US Veterans With Type 2 Diabetes) published on February 12, 2026, participants who started taking semaglutide were about 2 times more likely to develop NAION than participants who took sodium-glucose cotransporter-2 inhibitors

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Researchers collected data from 33,280 adults with type 2 diabetes living in Stockholm who started GLP-1 or DPP-IV therapy from 2008 to 2021 and had no record of using either class of drug in the year before initiation (mean age, 63.7 years