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During Listeria monocytogenes infection, LLO promotes mitochondrial membrane permeabilization, facilitating mtDNA release and subsequent activation of the cGAS-STING pathway ( Similarly, Salmonella enterica serovar Typhimurium infection induces mitochondrial stress and mtDNA release in murine macrophages, thereby activating the cGAS-STING-dependent type I IFN response (Xu et al., 2022)

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The area postrema is responsible for emesis and nausea and is likely the main contributor to these GLP-1 receptor agonist-associated side effects