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How GLP-1s Affect Calculator Accuracy Standard weight loss calculators may overestimate your calorie needs when on GLP-1 medications because: Reduced appetite means you naturally eat less than predicted Slower gastric emptying affects when and how much you can eat Enhanced satiety signals make smaller portions feel satisfying According to recent expert guidelines compiled by obesity research organizations, people on these medications typically consume 1,200 calories per day (women) and 1,500-1,800 calories per day (men)often less than traditional calculators suggest for weight loss