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The 545 amino acid isoform a protein is inactive but post-translational processing results in a 515 amino acid functional protein containing an acetylated alanine residue at the N-terminus

Bashir S, Banday M, Qadri O et al (2021) The molecular mechanism and functional diversity of UPR signaling sensor IRE1

Here we report on Spirulina platensis (SP), a natural microorganism commercially farmed worldwide as a food, as an efficient regulator of both synovial inflammation and osteoclast differentiation in male RA mouse models

These formulations utilize nanocarriers such as liposomes and polymeric nanoparticles to enhance bioavailability and target joint tissues, aiming to reduce systemic toxicity and dosing frequency