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R-96544 shows 100-fold higher affinity for the human 5HT 2A receptors than 5HT 1A , 5HT 1B , 5HT 1D , 5HT 5A , 5HT 6 , 5HT 7 receptors and 5-HT transporter, although R-96544 has relatively high affinity for 5HT 2C receptors (fourfold less compared to 5-HT 2A ) (21)

market as of April 2026 branded products still dominate because patents remain active

Wright, assistant professor at the Department of Physiology and Pharmacology at Karolinska Institutet, who is one of the researchers behind the study

He says there's very little data on whether or how the dose should be titrated to wean patients off, or how to adjust when your appetite and cravings start to return