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El tratamiento con OZEMPIC demostr reducciones sostenidas, estadsticamente superiores y clnicamente significativas en el valor de HbA1c (Figura 1) y el peso corporal por hasta 2 aos en comparacin con placebo y preparaciones de control activas (sitagliptina, insulina glargina, exenatida ER y dulaglutida)

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That translates to roughly 1-3% of patients in the oral formulation trials

Instead the Fab 3F52/ECD structure is compatible with a tilted conformation of the ECD, where Fab 3F52 occupies partially the orthosteric binding site of the GLP-1R TM domain explaining the competitive effect of Fab 3F52 on BMS21-induced activation of GLP-1R (Fig