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This functional improvement was associated with intermediate-conductance Ca 2+ -activated K + channels (KCa3.1) via the mitogen-activated protein kinase/extracellular-signal-regulated kinase (MEK/ERK) and phosphoinositide 3-kinases (PI3K), serine/threonine protein kinase B (PKB

However, the authors suggest that future larger and longer trials are needed to fully assess the efficacy and safety of this treatment combination

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