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The third is duration and safety : short controlled studies in animals say almost nothing about what months or years of exposure would do in a human, which is precisely why the cycling section defaults to scheduled off periods rather than open-ended use

these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

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