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Abstract Among the most impactful therapeutic advances in the management of diabetes over the past two decades has been the development of incretin-based therapies, specifically glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) and in combination with glucose-dependent insulinotropic polypeptide (GIP) RAs

The IC 50 value, which represents half the maximum concentration of a substance that inhibits a specific biological function in vitro , was determined using this assay

however, current human evidence remains limited, heterogeneous, and largely associative

When the barrier between the gut and the bloodstream weakens, bacterial fragments and other compounds can cross where they do not belong, and the immune system responds